Once-daily ceftriaxone for skin and soft tissue infections.

Ceftriaxone therapy of serious bacterial infections in adults.

We evaluated the efficacy and safety of ceftriaxone in 50 adults with serious infections, usually giving 1 g every 12 h. Of the 35 patients who could be evaluated for clinical efficacy, 15 had failed on previous therapy, 15 had nosocomial infections, and all but 1 had underlying diseases. One patient had three sites of infection. Favorable responses were seen in 34 of 37 infections, including 1...

730A Retrospective Comparison of Self – Administered Ceftriaxone vs Cefazolin for Methicillin-Susceptible Staphylococcus Aureus Bacteremia in an Outpatient Antibiotic Therapy Setting.

Background. MSSA bacteremia is a common cause of community-acquired and hospital-acquired infections with significant morbidity and mortality. Ceftriaxone is a third generation cephalosporin with activity against gram positive and gram negative aerobic bacteria including MSSA. It is well tolerated and offers significant cost reduction with its once daily dosing in the outpatient setting. Althou...

Experience with High Dose Once-daily Vancomycin for Patients with Skin and Soft-tissue infections in an Ambulatory Setting

P-231: The Effect of Ceftriaxone on Testicular Tissue of Adult Male Mice

Background: Ceftriaxone is an antibiotic used for treating respiratory,skin,bone and kidney infections. Our purpose was investigating effect of ceftriaxone on testicular tissue. Materials and Methods: 40 mice with 6 weeks old were used in this study. The mice randomly were divided into 2 groups, control- sham and test groups. The test group was subdivided to IP1 and IP2 which received Ceftriaxo...

Once-daily oral gatifloxacin versus oral levofloxacin in treatment of uncomplicated skin and soft tissue infections: double-blind, multicenter, randomized study.

This was a double-blind, multicenter study in which 410 adults (> or =18 years of age) with uncomplicated skin and soft tissue infections (SSTIs) were randomized to receive either 400 mg of gatifloxacin orally once daily or 500 mg of levofloxacin orally once daily for 7 to 10 days. The study protocol called for four assessments-before and during treatment, at the end of treatment, and posttreat...